Journal article
Obesity is associated with lower coronary microvascular density
DJ Campbell, JB Somaratne, DL Prior, M Yii, JF Kenny, AE Newcomb, DJ Kelly, MJ Black
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Background: Obesity is associated with diastolic dysfunction, lower maximal myocardial blood flow, impaired myocardial metabolism and increased risk of heart failure. We examined the association between obesity, left ventricular filling pressure and myocardial structure. Methods: We performed histological analysis of non-ischemic myocardium from 57 patients (46 men and 11 women) undergoing coronary artery bypass graft surgery who did not have previous cardiac surgery, myocardial infarction, heart failure, atrial fibrillation or loop diuretic therapy. Results: Non-obese (body mass index, BMI, ≤30 kg/m2, n=33) and obese patients (BMI >30 kg/m2, n=24) did not differ with respect to myocardial t..
View full abstractRelated Projects (1)
Grants
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This work was funded by grants from the National Health and Medical Research Council of Australia and from the National Heart Foundation of Australia. Duncan Campbell (Grant ID 395508) and Darren Kelly (Grant ID 566867) are recipients of Senior Research Fellowships from the National Health and Medical Research Council of Australia. St Vincent's Institute of Medical Research is supported in part by the Victorian Government's Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.